Interactive model
See the peroxide DuraRad clears.
As a radiopharmaceutical decays, radiolysis generates hydrogen peroxide inside the vial. This model, built from published radiolysis yields and DuraRad's measured peroxide-clearance rate, shows how much an uncoated vial accumulates over a modeled storage window, and how much a DuraRad-coated vial clears.
Interactive radiolysis model
Load a clinical preset for a five-second read, or open the model to set the isotope, vial format, dose, and storage window yourself. The default window is two half-lives, chosen so the full accumulation curve is visible rather than any one product's labeled expiry; shorten it to your product's expiry to read the burden over the real window. Every figure here is modeled, not measured under irradiation, and each result carries that status with it.
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Modeled reduction in cumulative peroxide exposure
99.9%
Not a measure of drug protected
Modeled from measured peroxide clearance in DuraRad vials and literature radiolysis yields. Radioactive validation designed and scheduled for Q4 2026 at Washington University in St. Louis.
- Uncoated peak
- 1.59 mM
- DuraRad peak
- 1.69 µM
Over 13.3 days, DuraRad holds cumulative peroxide exposure about 99%+ lower than a no-sink uncoated vial for this scenario.
Interactive model: enable JavaScript to explore isotopes, vial formats, and clinical doses.
Scroll the chart
Modeled reduction in cumulative peroxide exposure
99.9%
Not a measure of drug protected
Modeled from measured peroxide clearance in DuraRad vials and literature radiolysis yields. Radioactive validation designed and scheduled for Q4 2026 at Washington University in St. Louis.
- Uncoated peak
- 1.59 mM
- DuraRad peak
- 1.69 µM
Over 13.3 days, DuraRad holds cumulative peroxide exposure about 99%+ lower than a no-sink uncoated vial for this scenario.
Calibrate Model parameters & per-case detail
Beta emitter, t½ = 6.647 days
Inner diameter: 22.0 mm
Standard Pluvicto dose (7.4 GBq)
Default: 2 half-lives (13.3 days)
Adds a spec line + time-to-threshold on run.
Uncoated vial
DuraRad-coated vial
| Isotope | Activity | Vial / fill | Uncoated peak | DuraRad peak | Peak reduction |
|---|
Model & assumptions
Modeled from measured peroxide clearance in DuraRad vials and literature radiolysis yields. Radioactive validation designed and scheduled for Q4 2026 at Washington University in St. Louis.
Model & validation detail
Pseudo-first-order H₂O₂ clearance, k = 0.107 min⁻¹ (Batch 2, 6R / 3.0 mL). Generation from literature G-values. Performance under continuous irradiation not yet validated.
- Radiolytic H₂O₂ generation from published literature G-values (LET-dependent); isotope decay reduces the source term over time.
- DuraRad clearance is pseudo-first-order; k_eff scales the measured reference rate constant by the vial's surface-area-to-volume ratio.
- Assumes a well-mixed vial, sustained enzyme activity, and no irradiation-induced enzyme loss: the open assumption the Q4 2026 radioactive validation is designed to close.
How to read it
A physics-grounded model, built to be checked.
The uncoated curve is an upper bound, not a typical vial: it assumes no removal of any kind, no radiolytic steady state and none of the scavengers a real formulation carries, so it traces the most peroxide the physics could accumulate rather than what an average uncoated vial holds. The DuraRad curve adds first-order enzymatic clearance at the vial wall, so peroxide is consumed about as fast as radiolysis makes it, and the concentration is held to a low quasi-steady state across the modeled window.
The suppression magnitude is modeled from DuraRad's measured peroxide-clearance rate constant, k = 0.107 min⁻¹, and literature G-values. Performance under continuous irradiation is not yet validated. That is exactly the open assumption the Q4 2026 radioactive study is designed to close.
Slow-decay isotopes such as Lu-177 show the largest modeled suppressions, because enzymatic clearance easily outpaces a source term that barely fades over the modeled window. Fast decayers and high-LET alpha emitters behave differently. Open the model and compare them side by side.
Modeled from measured peroxide clearance in DuraRad vials and literature radiolysis yields. Radioactive validation designed and scheduled for Q4 2026 at Washington University in St. Louis.
Model & validation detail
Pseudo-first-order H₂O₂ clearance, k = 0.107 min⁻¹ (Batch 2, 6R / 3.0 mL). Generation from literature G-values. Performance under continuous irradiation not yet validated.
Want the model behind the model?
The full parameterization, the assumptions, and the design of the radioactive validation study are in the DuraRad data package.